ETV:IDS has improved brain uptake compared with IgG:IDS in TfRmu/huKI mice. (A–C) Serum (A), liver (B), and brain (C) concentrations of ETV:IDS or IgG:IDS from TfRmu/hu KI mice were measured 0.5, 4, 8, and 24 h after an IV dose of 1, 3, or 10 mg/kg and determined using an IDS capture/IDS detect immunoassay. TfRmu/hu KI mice are on a C57BL/6 background. Data presented are from a single study. ELISA data represent the average of n = 2 technical replicates per mouse; each symbol represents an average of n = 3–5 mice per group per time point; graphs display mean ± SD.
Figure 2.

ETV:IDS has improved brain uptake compared with IgG:IDS in TfR mu/hu KI mice. (A–C) Serum (A), liver (B), and brain (C) concentrations of ETV:IDS or IgG:IDS from TfRmu/hu KI mice were measured 0.5, 4, 8, and 24 h after an IV dose of 1, 3, or 10 mg/kg and determined using an IDS capture/IDS detect immunoassay. TfRmu/hu KI mice are on a C57BL/6 background. Data presented are from a single study. ELISA data represent the average of n = 2 technical replicates per mouse; each symbol represents an average of n = 3–5 mice per group per time point; graphs display mean ± SD.

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