Liver histology and CD34 expression in humans and mice with GIMAP5 deficiency.(A) Photomicrographs of abnormal CD34 immunostaining in liver sinusoids of four unrelated patients (P1-1, P2-1, P3-1, and P4-1) as compared with an unaffected control. (B) Photomicrographs of abnormal CD34 sinusoidal expression is shown in the liver sections from C57BL/6 Gimap5sph/sph mice at 2, 3, and >7 wk old and in adult C57BL/6 Gimap5sph/sphRag1−/− mice as compared with Gimap5sph/+ control mice. Histological data from 2-wk-old, 3-wk-old, adult Gimap5sph/sph, and adult Gimap5sph/sphRag1−/− mice was verified at least four, two, seven, and three independent times, respectively. Littermates were used as controls. Scale bar = 50 µm.
Figure 2.

Liver histology and CD34 expression in humans and mice with GIMAP5 deficiency. (A) Photomicrographs of abnormal CD34 immunostaining in liver sinusoids of four unrelated patients (P1-1, P2-1, P3-1, and P4-1) as compared with an unaffected control. (B) Photomicrographs of abnormal CD34 sinusoidal expression is shown in the liver sections from C57BL/6 Gimap5sph/sph mice at 2, 3, and >7 wk old and in adult C57BL/6 Gimap5sph/sphRag1−/− mice as compared with Gimap5sph/+ control mice. Histological data from 2-wk-old, 3-wk-old, adult Gimap5sph/sph, and adult Gimap5sph/sphRag1−/− mice was verified at least four, two, seven, and three independent times, respectively. Littermates were used as controls. Scale bar = 50 µm.

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