Proposed model for DMSR. DSBs are repaired by NHEJ repair process in G1 or G0 cells, which is accompanied by DNA-PK activation. Activated DNA-PK induces PCM accumulation at the centrosome and interphase centrosome maturation, during which pT308 AKT also accumulated on the centrosome. The 53BP1-Shieldin complex is involved in the regulation of this process (left). Elevated microtubule dynamics will promote DSB mobility, which facilitates the c-NHEJ repair (right).