Schematic view of the c-ferroptotic cell death pathway triggered by heat shock in Synechocystis sp. PCC 6803 cells . Early GSH depletion following the heat shock leads to lipid peroxidation, mostly of PUFAs from thylakoid and plasma membranes. CPX, Lipro-1, vitamin E (vitE), or Fer-1, canonical ferroptosis inhibitors, prevent the accumulation of toxic ROS, inhibiting ferroptotic cell death. Intracellular calcium is a messenger in c-ferroptosis cell death pathways, and BAPTA-AM can suppress this signal and prevent this cell death pathway triggered by heat shock in Synechocystis sp. PCC 6803 cells.