Schematic of sarcomere. Nebulin’s C terminus is anchored in the Z-disk and its N terminus is near the thin filament pointed end. Shown is the domain structure with super-repeats (blue) and Z-repeats (gray), the 8 simple repeats at the N terminus (orange), 12 simple repeats at the C terminus, linker repeats (orange), the highly conserved triplicate (yellow), serine-rich region (brown), and SH3 at nebulin’s C terminus (green).