Figure 2.

Nav current in mouse CCs exhibits two components of recovery from inactivation, generally similar to that in rat CCs. (A) Example paired-pulse recovery protocol with recovery at −80 mV following a 5-ms inactivation step at 0 mV. Right: Aligned P1 and P2 currents are shown. (B) Traces show the time course of recovery from inactivation at a −120-mV recovery potential for the same cell as in A. (C) Averaged time course (± SD) of recovery for mouse CCs at the indicated voltages along with best fit double exponential function given by I(t) = Af*[1 − exp(−t / τf)] + As*[1 − exp(−t/τs)], where I(t) is fractional recovery, Af and As are fraction fast and slow recovery, respectively, and τf and τs are time constants of fast and slow recovery, respectively. For −120 mV (n = 12 cells), Af = 0.46 ± 0.02, τf = 2.17 ± 0.31 ms, As = 0.56 ± 0.02, τs = 83.3 ± 10.2 ms. For −100 mV (n = 12 cells), Af = 0.48 ± 0.02, τf = 4.38 ± 0.49 ms, As = 0.54 ± 0.02, τs = 335.3 ± 43.1 ms. For −80 mV (n = 18 cells), Af = 0.45 ± 0.01, τf = 9.38 ± 0.75 ms, As = 0.56 ± 0.02, τs = 660.5 ± 70.4 ms. For −60 mV (n = 8 cells), Af = 0.29 ± 0.01, τf = 32.4 ± 2.7 ms, As = 0.49 ± 0.02, τs = 1,336.4 ± 176.0 ms. (D) Fits of recovery from inactivation in rat CCs from our associated paper (Martinez-Espinosa et al., 2021).

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