The TMEM16 scramblase module. A vastly oversimplified cartoon illustrating how disparate regulators of TMEM16 scramblases come together as a “module” employed in many cells to individually tune the “brightness” of the scrambling. This tuning would undoubtedly alter the speed at which a cell promotes lipid redistribution in response to Ca²⁺, as well as the extent that scrambling alters the exposure of cytofacial lipid species and the physical characteristics of the PM during scrambling.