Figure 9.
Hill plot of CaV1.1 WT and R174W channels activity highlights the intrinsic voltage dependence of the pore. The filled circles represent the Hill-transformed experimental G(V) data points for WT and R174W channels. Continuous lines are the Hill-transformed G(V) curves predicted by the allosteric model. Dashed lines correspond to straight lines with slope of 1.7 e / kT obtained as described in the text. Note that the two channels exhibit a difference in the overall pore–VSD coupling energy (ΔΔG) of 59 meV (as estimated from ΣWi for the WT and R174W obtained from the model best fit).

Hill plot of CaV1.1 WT and R174W channels activity highlights the intrinsic voltage dependence of the pore. The filled circles represent the Hill-transformed experimental G(V) data points for WT and R174W channels. Continuous lines are the Hill-transformed G(V) curves predicted by the allosteric model. Dashed lines correspond to straight lines with slope of 1.7 e / kT obtained as described in the text. Note that the two channels exhibit a difference in the overall pore–VSD coupling energy (ΔΔG) of 59 meV (as estimated from ΣWi for the WT and R174W obtained from the model best fit).

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