Distinct sites of action for Kv7 channel activators. Likely regions of binding and the location of implicated amino acid residues are highlighted on a homology model of Kv7.2 based on PDB accession no. 5VMS. The critical tryptophan in the retigabine binding site is highlighted in yellow (Schenzer et al., 2005). Voltage sensor residues that influence effects of ICA-069673 are highlighted in cyan (Peretz et al., 2010; Li et al., 2013). Voltage sensor residues that influence ARA-S effects are highlighted in red (Larsson et al., 2020).