Predicted pore structure of hASIC1a in the closed conformation. Side view of the ion permeation pathway in the predicted resting conformation of hASIC1a (left panel). Only two subunits are shown for clarity. The TM domains are colored teal, and the reentrant loops are pink. A zoomed-in side view of the ion permeation pathway is shown with the following residues lining the permeation pathway: G444, H28, T26, S25, S24, and S23 (right panel).