R92Q causes cellular hypercontractility in hiPSC-CMs. Single hiPSC-CMs were seeded on rectangular patterns on 10-kPa hydrogels for traction force microscopy. (A–C) Cumulative distributions reveal that R92Q hiPSC-CMs have a greater total force (A), contraction speed (B), and contraction power (C) compared with WT. WT data are from Clippinger et al. (2019). Values from the analysis, number of cells examined, 95% confidence intervals obtained from bootstrapping, and P values derived from the distributions of bootstrapped values are listed in the table.