Deactivation kinetics are largely unaffected by LOP. (A) Representative tail currents at −80 mV (following a 20-ms depolarization to 90 mV) with 0 (black traces), 3 µM (red), and 10 µM LOP (blue). Complete trace is shown in inset at right. (B) Representative tail currents at −120 mV, with complete trace shown in inset. (C and D) Tail currents from A and B normalized to the same amplitude. Dashed lines represent single exponential fits to each trace (τ at −80 mV = 2.02, 2.25, and 1.73 ms for 0, 3, and 10 µM LOP, respectively; τ at −120 mV = 0.929, 0.876, and 0.694 ms for 0, 3, and 10 µM LOP, respectively). (E and F) Means of normalized tail currents; SEM is shown as shaded regions. Dashed lines represent single exponential fits to each mean trace (τ at −80 mV = 1.82, 1.99, and 1.77 ms for 0, 3, and 10 µM LOP, respectively; τ at −120 mV = 0.86, 0.82, and 0.85 ms for 0, 3, and 10 µM LOP, respectively).