Inward rectification of GluA1 A8C and L10C. (A–D) Currents evoked by 100 µM kainate, 400 µM Cd alone or together with kainate during voltage ramps from −150 to +120 mV. (E) Rectification index (mean ± SEM ratio of current at −60 mV to +40 mV; 5–11 cells per construct) for currents evoke by kainate, Cd alone, or together with kainate. Higher index values indicate stronger rectification. Values for GluA1 L10C + γ-2 TARP were significantly greater than for GluA1 A8C expressed alone or together with γ-2 (2-way ANOVA with post hoc Student–Newman–Keuls test).