Genetic analysis of P1 . (A) Principal component analysis (PCA) for P1. Although there are no Polynesians included in the PCA for triangulation of P1’s ancestry, individuals of Polynesian ancestry often locate on visualizations of the first and second principal components adjacent to East Asian samples (Minster et al., 2016). (B) Filtering criteria used for the single-nucleotide variant (SNV) analysis of WES results for P1. CADD, combined annotation-dependent depletion; GDI, gene damage index.