Figure 7. Mutational effect on the... | Rockefeller University Press

Figure 7.

Mutational effect on the goodness of the global fit. (A) Fit of 16 CARs with the CHA16 model. The fit was started with no mutational effect, i.e., all fdx values were set to 1 (left). Then each fdx was systematically decreased 110 times by a factor to reach, after 100 steps, the true fdx value, and 10 steps further. The big gray double arrow illustrates that the fdx values were varied. The brackets in the legends indicate closely similar data points and curves. (B)Ki as function of the factor by which fdx was decreased to reach, after 100 steps, the true value (arrow). The four fdx values are plotted in the top scheme. (C) Imprecisions iprKi,sm as functions of the factor by which fdx was decreased to reach, after 100 steps, the true value. The values correspond to the plot in B.

Mutational effect on the goodness of the global fit. (A) Fit of 16 CARs with the CHA₁₆ model. The fit was started with no mutational effect, i.e., all fdx values were set to 1 (left). Then each fdx was systematically decreased 110 times by a factor to reach, after 100 steps, the true fdx value, and 10 steps further. The big gray double arrow illustrates that the fdx values were varied. The brackets in the legends indicate closely similar data points and curves. (B)K_i as function of the factor by which fdx was decreased to reach, after 100 steps, the true value (arrow). The four fdx values are plotted in the top scheme. (C) Imprecisions ipr_Ki,sm as functions of the factor by which fdx was decreased to reach, after 100 steps, the true value. The values correspond to the plot in B.