Figure 6. Effects of the data point... | Rockefeller University Press

Figure 6.

Effects of the data point number on the goodness of the global fit. (A) Fit of 16 CARs with the CHA16 model. 35 equidistant ligand concentrations were used as data points in the CHA16 model, and the number of data points per CAR was increased such that reducing the CAR number kept in total 560 data points. The noise level was set to 0.25. The brackets in the legends indicate closely similar data points and curves. The big gray double arrow illustrates that the CAR combination is varied. (B) Plot of the imprecisions iprKi = σKi,rel for the 32 Ki values as function of the 95 CAR combinations. (C) Plot of the mean imprecision, iprKi,sm, for the 32 Ki values as function of the 95 CAR combinations for a constant total number of 560 data points (red) compared with 35 data points per CAR (blue). At intermediate numbers of included CARs, iprKi,sm is slightly lower for a constant total number of 560 data points (inset).

Effects of the data point number on the goodness of the global fit. (A) Fit of 16 CARs with the CHA₁₆ model. 35 equidistant ligand concentrations were used as data points in the CHA₁₆ model, and the number of data points per CAR was increased such that reducing the CAR number kept in total 560 data points. The noise level was set to 0.25. The brackets in the legends indicate closely similar data points and curves. The big gray double arrow illustrates that the CAR combination is varied. (B) Plot of the imprecisions ipr_Ki = σ_Ki,rel for the 32 K_i values as function of the 95 CAR combinations. (C) Plot of the mean imprecision, ipr_Ki,sm, for the 32 K_i values as function of the 95 CAR combinations for a constant total number of 560 data points (red) compared with 35 data points per CAR (blue). At intermediate numbers of included CARs, ipr_Ki,sm is slightly lower for a constant total number of 560 data points (inset).