Comparison between mouse Piezo1 and mouse Piezo2. (A) Top: Snake plot of mouse Piezo1 (Uniprot accession no. E2JF22) illustrating the TMs and loops. Each circle represents one amino acid. Bottom: Identical snake plot of mouse Piezo2 (Uniprot accession no. Q8CD54). Helical bundles are colored as in Fig. 1 A. Interbundle loops are colored according to the preceding bundle. The N- and C-terminal loops are shown in gray, the outer helix is shown in pink, the inner helix is shown in orange, and the cap domain is shown in light blue. (B) Conservation of individual TMs between mouse Piezo1 and mouse Piezo2. Bars are organized into bundles and colored as in A. Amino acid identity is shown in filled bars, and similarity is shown in outlined bars for each helix. (C) Same as in B, but for all loops.