Figure 2.
Oleoyl-CoA regulation of K2P channels.(A) Fold activation (blue) and inhibition (percent; brown) of K2P channels at +40 mV by 10 µM oleoyl-CoA measured as in B and C. Insensitive channels are highlighted in gray. Number of independent experiments is indicated next to the bars. Data are summarized in Table S2. (B) Representative current traces (right) and analyzed currents at +40 mV plotted over time (left) of TRAAK and TALK-2 channels measured in voltage ramps between −80 and +80 mV in excised inside-out patches of Xenopus oocytes using control bath solution and in the presence of 10 µM oleoyl-CoA or 5 mg ml−1 BSA. (C) Representative current traces of TASK-2 and TWIK-1* channels measured and analyzed as in B. All data are presented as mean ± SEM. n. d., not determined.

Oleoyl-CoA regulation of K2P channels. (A) Fold activation (blue) and inhibition (percent; brown) of K2P channels at +40 mV by 10 µM oleoyl-CoA measured as in B and C. Insensitive channels are highlighted in gray. Number of independent experiments is indicated next to the bars. Data are summarized in Table S2. (B) Representative current traces (right) and analyzed currents at +40 mV plotted over time (left) of TRAAK and TALK-2 channels measured in voltage ramps between −80 and +80 mV in excised inside-out patches of Xenopus oocytes using control bath solution and in the presence of 10 µM oleoyl-CoA or 5 mg ml−1 BSA. (C) Representative current traces of TASK-2 and TWIK-1* channels measured and analyzed as in B. All data are presented as mean ± SEM. n. d., not determined.

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