Ang 1–7 did not prevent the decrease in fiber CSA associated with 28-d denervation, but A779 significantly worsened the decrease in CSA in soleus. (A) Mean fiber CSA values; fiber CSA distribution of (B) innervated, denervated soleus without or with Ang 1–7 treatment; (C) innervated, sucrose-treated, and DIZE-treated denervated soleus. CSA values were divided in bin of 100 µm², and the number of fibers in each bin is presented as a percentage of the total number of fibers analyzed. The CSA frequency distribution was first determined for each muscle, and then mean and SE (vertical bars) were calculated from four or five muscles (with a total number of fibers ranging between 1,970 and 3,850). *, CSA distribution was significantly shifted toward lower CSA when compared with innervated; §, CSA distribution was significantly shifted toward lower CSA when compared with denervated or denervated/sucrose (ANOVA and LSD, P < 0.05).