Concentration dependence of simulated Zn²⁺ effects on Ca_v2.3 channels. (A–F) Comparison of measured and simulated concentration dependencies for Zn²⁺-induced changes in half-activation voltage (A), activation time constant at 10 mV (B), apparent V_rev (C), deactivation time constant at −50 mV (D), half-inactivation voltage (E), and activation slope factor (F).