Figure 2. MthK channel blockade by SPM 4... | Rockefeller University Press

Figure 2.

MthK channel blockade by SPM4+.(A) Mean normalized macroscopic MthK currents. Currents were obtained over a range of [SPM4+] (≤100 µM) using a voltage-ramp protocol and normalized as described in Fig. 1. (B) Fractional current versus [SPM4+] plotted at five representative voltages. Data were fitted with Hill equations (smooth curves) to estimate Kapp over a range of voltages. (C)Kapp versus voltage, fitted with Eq. 1 (solid blue line; Kapp(0) = 77 ± 6 µM, zδ = 0.88 ± 0.05 e0).

MthK channel blockade by SPM⁴⁺. (A) Mean normalized macroscopic MthK currents. Currents were obtained over a range of [SPM⁴⁺] (≤100 µM) using a voltage-ramp protocol and normalized as described in Fig. 1. (B) Fractional current versus [SPM⁴⁺] plotted at five representative voltages. Data were fitted with Hill equations (smooth curves) to estimate K_app over a range of voltages. (C)K_app versus voltage, fitted with Eq. 1 (solid blue line; K_app(0) = 77 ± 6 µM, zδ = 0.88 ± 0.05 e₀).

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