Figure 6.
Acceleration of recovery from inactivation of Nav1.4 by β1, β1-ChR2, and β1-ChR2-ChR2. The respective voltage protocol is shown on the right. During the first pulse (500 ms at −10 mV), Nav1.4 channels were activated; subsequently they accumulated in the inactivated state. During the time interval Δt, channels were allowed to recover at −120 mV. The second test pulse to −20 mV was used to determine the respective fraction of non-inactivated channels. Coexpression of β1 as well as both ChR2-coupled β1 subunits accelerated this recovery process. Data points are from two oocyte batches and four to eight different recordings. For statistics, see Table 1. Error bars represent SEM.

Acceleration of recovery from inactivation of Nav1.4 by β1, β1-ChR2, and β1-ChR2-ChR2. The respective voltage protocol is shown on the right. During the first pulse (500 ms at −10 mV), Nav1.4 channels were activated; subsequently they accumulated in the inactivated state. During the time interval Δt, channels were allowed to recover at −120 mV. The second test pulse to −20 mV was used to determine the respective fraction of non-inactivated channels. Coexpression of β1 as well as both ChR2-coupled β1 subunits accelerated this recovery process. Data points are from two oocyte batches and four to eight different recordings. For statistics, see Table 1. Error bars represent SEM.

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