Figure 3.
Chlorpromazine occludes D1R-induced increase in CaV2.2 currents in transfected HEK293T cells. Representative traces and averaged CaV2.2 currents (ICav2.2) from HEK293T cells cotransfected with CaV2.2, CaVα2δ1, CaVβ3, and either D1R (+D1R −CPZ; n = 12) or empty plasmid (−D1R −CPZ; n = 15), preincubated (+D1R +CPZ; n = 12) or not (−D1R +CPZ; n = 10) with chlorpromazine (CPZ; 1 µM). One-way ANOVA with Dunn’s post-test versus −D1R −CPZ. n.s., nonstatistically significant. Data were expressed as mean ± SEM, and dots represent individual data points.

Chlorpromazine occludes D1R-induced increase in CaV2.2 currents in transfected HEK293T cells. Representative traces and averaged CaV2.2 currents (ICav2.2) from HEK293T cells cotransfected with CaV2.2, CaVα2δ1, CaVβ3, and either D1R (+D1R −CPZ; n = 12) or empty plasmid (−D1R −CPZ; n = 15), preincubated (+D1R +CPZ; n = 12) or not (−D1R +CPZ; n = 10) with chlorpromazine (CPZ; 1 µM). One-way ANOVA with Dunn’s post-test versus −D1R −CPZ. n.s., nonstatistically significant. Data were expressed as mean ± SEM, and dots represent individual data points.

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