Figure 5.
Association of the S1–S4 domain with the pore domain in representative TRP and Kv channels. TRP channel voltage-sensor like domain (VSLD; cyan) typically associates with pore domain from an adjacent subunit (orange; red) via a larger interface and thus remains relatively static during channel gating as compared with VGICs. The potential hydrophobic interactions between the S3 and S6 helices in TRPV4 are highlighted with sticks. PDB accession nos. are as follows: Kv2.1 (2R9R), TRPM4 (6BQR), TRPML1 (5WJ5), and TRPV4 (6BBJ).

Association of the S1–S4 domain with the pore domain in representative TRP and Kv channels. TRP channel voltage-sensor like domain (VSLD; cyan) typically associates with pore domain from an adjacent subunit (orange; red) via a larger interface and thus remains relatively static during channel gating as compared with VGICs. The potential hydrophobic interactions between the S3 and S6 helices in TRPV4 are highlighted with sticks. PDB accession nos. are as follows: Kv2.1 (2R9R), TRPM4 (6BQR), TRPML1 (5WJ5), and TRPV4 (6BBJ).

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