Representative structures of each of the seven TRP subfamilies. TRP channels are shown in ribbon diagrams viewed parallel to the membrane, with each subunit color-coded differently. Note, TRP channels are decorated with unique soluble domains outside the relatively conserved transmembrane core structure embedded within the lipid bilayer delimited with two black horizontal lines. PDB accession nos. are as follows: TRPV1 (3J5P), TRPA1 (3J9P), TRPM2 (6MIX), TRPC3 (6CUD), no mechanoreceptor potential C (NOMPC; 5VKQ), PKD2 (5T4D), and TRPML1 (5WJ5).