Ca2+ transients during repetitive stimulation.(A) Representative mag-fluo-4 (ΔF/F0) traces during the 1st, 2nd, 20th, and 40th stimulus trains in FDB fibers from WT and CASQ1-null mice. (B) Time course of relative change in peak mag-fluo-4 fluorescence during 40 consecutive stimulus trains. (C and D) Quantitative analyses of the relative decay during the second stimulus train (ST2nd/ST1st; C) and the peak of the bump phase (STpeak/ST2nd; D) from the data shown in B. Data are shown as mean ± SEM; *, P < 0.05. Numbers in bars (n) indicate the number of FDB fibers analyzed. Number of mice: n = 4 WT; n = 5 CASQ1-null.
Figure 5.

Ca2+ transients during repetitive stimulation. (A) Representative mag-fluo-4 (ΔF/F0) traces during the 1st, 2nd, 20th, and 40th stimulus trains in FDB fibers from WT and CASQ1-null mice. (B) Time course of relative change in peak mag-fluo-4 fluorescence during 40 consecutive stimulus trains. (C and D) Quantitative analyses of the relative decay during the second stimulus train (ST2nd/ST1st; C) and the peak of the bump phase (STpeak/ST2nd; D) from the data shown in B. Data are shown as mean ± SEM; *, P < 0.05. Numbers in bars (n) indicate the number of FDB fibers analyzed. Number of mice: n = 4 WT; n = 5 CASQ1-null.

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