Figure S9.
Simulated dynamics of phosphoinositide probes during receptor activation (shaded area) using the expanded mathematical model.(A–E) The rate constants for PI4K activity are varied as in Fig. 7 A. Corresponding simulated time courses of concentration of PM PtdIns4P-bound P4M (A), Golgi PtdIns4P-bound PHFAPP1 (B), PM PtdIns(4,5)P2-bound PHPLCδ1 (C), Ins(1,4,5)P3-bound LIBRAvIII (D), and DAG-bound C1A (E). _G indicates chemical species in the Golgi compartment.

Simulated dynamics of phosphoinositide probes during receptor activation (shaded area) using the expanded mathematical model. (A–E) The rate constants for PI4K activity are varied as in Fig. 7 A. Corresponding simulated time courses of concentration of PM PtdIns4P-bound P4M (A), Golgi PtdIns4P-bound PHFAPP1 (B), PM PtdIns(4,5)P2-bound PHPLCδ1 (C), Ins(1,4,5)P3-bound LIBRAvIII (D), and DAG-bound C1A (E). _G indicates chemical species in the Golgi compartment.

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