Calcium buffers and CBPs modify all aspects of calcium dynamics. (a) Spatial dynamics at 2 ms for spherical spines with different buffer conditions: control (with both fixed and mobile buffers), only fixed buffers, only mobile buffers, and a lumped exponential decay. While all buffer cases show relatively similar peak concentrations (d), all other quantifications show that buffer type greatly impacts the calcium transient decay time (a–c). Temporal dynamics (b) show that the control and fixed buffer cases have much faster decay, which translates into lower AUC values (c).