Figure 6. Localization of membrane fluxes alters the spatiotemporal dynamics of calcium. (a) Spatial dynamics at 2 ms for spherical and ellipsoidal spines with only one of VSCC or NMDAR as the calcium source. When the main calcium source is the VSCC, we see a more uniform concentration with the main gradient between the spine head and spine neck. When the NMDAR is the main calcium source, we see a large spatial gradient with a higher concentration at the PSD, because the NMDAR is localized to the PSD. (b) Temporal dynamics for spherical and ellipsoidal spines with either the VSCC or NMDAR as the calcium source. Temporal dynamics clearly show that VSCCs act on a faster timescale and have a higher peak calcium when compared with the NMDARs. However, NMDAR influx leads to a more prolonged calcium transient.
Figure 6.

Localization of membrane fluxes alters the spatiotemporal dynamics of calcium. (a) Spatial dynamics at 2 ms for spherical and ellipsoidal spines with only one of VSCC or NMDAR as the calcium source. When the main calcium source is the VSCC, we see a more uniform concentration with the main gradient between the spine head and spine neck. When the NMDAR is the main calcium source, we see a large spatial gradient with a higher concentration at the PSD, because the NMDAR is localized to the PSD. (b) Temporal dynamics for spherical and ellipsoidal spines with either the VSCC or NMDAR as the calcium source. Temporal dynamics clearly show that VSCCs act on a faster timescale and have a higher peak calcium when compared with the NMDARs. However, NMDAR influx leads to a more prolonged calcium transient.

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