Pocket volume and d_x. Resting, brown and active, green. (a) Top: Pocket volume. With all agonists, α−γ is the smallest (^AR and ^AR*). At all sites, ^AR* is smaller than ^AR (all agonists) and pocket volume is smallest with TMA. Bottom: d_x. Distance between the agonist’s principal nitrogen and the pocket center is approximately twofold smaller in ^AR* versus ^AR (all sites and agonists). (b) Example d_x distributions. Each panel shows results from two MD trajectories (α−γ).