Figure 5.
Figure 5. Effects of CCh or Iso on IF in isolated rabbit SN cells pretreated with PI-103. (A) Typical traces of IF activation in cells treated for 2 h with 500 nM PI-103 alone or treated with PI-103 and then exposed to 1 µM CCh or 10 µM Iso for 5 min. (B) Boltzmann fit of 1-s IC activation curves for IF. V1/2 and K were derived from the curves. PI-103, V1/2 = −90.2 mV, K = 9.2 mV; PI-103 + CCh, V1/2 = −97.1 mV, K = 9.3 mV; PI-103 + Iso, V1/2 = −78.4 mV, K = 13.4 mV. (C) Summary data of IF density measured at −110 mV from a holding potential of −30 mV. Numbers above the bars indicate the number of cells examined. Summarized data show mean ± SEM.

Effects of CCh or Iso on IF in isolated rabbit SN cells pretreated with PI-103. (A) Typical traces of IF activation in cells treated for 2 h with 500 nM PI-103 alone or treated with PI-103 and then exposed to 1 µM CCh or 10 µM Iso for 5 min. (B) Boltzmann fit of 1-s IC activation curves for IF. V1/2 and K were derived from the curves. PI-103, V1/2 = −90.2 mV, K = 9.2 mV; PI-103 + CCh, V1/2 = −97.1 mV, K = 9.3 mV; PI-103 + Iso, V1/2 = −78.4 mV, K = 13.4 mV. (C) Summary data of IF density measured at −110 mV from a holding potential of −30 mV. Numbers above the bars indicate the number of cells examined. Summarized data show mean ± SEM.

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