Figure 10. Effect of the Ano1 inhibitor benzbromarone on sharp electrode LMC membrane potential of pressurized IALV. Representative 20-s membrane potential recording made with sharp electrode impalement of a LMC from a pressurized IALV under control perfusion with Krebs solution (A) and in response to 5 µM benzbromarone (B). The recorded action potentials were analyzed to assess: action potential frequency (C), resting membrane potential (D), the linear diastolic depolarization rate (E), action potential initiation threshold potential (F), the steepness of the action potential upstroke (G), peak voltage achieved during the action potential (H), the plateau voltage (I), and plateau duration (J). *, P < 0.05 comparing 5 µM benzbromarone versus Krebs at n = 6.
Figure 10.

Effect of the Ano1 inhibitor benzbromarone on sharp electrode LMC membrane potential of pressurized IALV. Representative 20-s membrane potential recording made with sharp electrode impalement of a LMC from a pressurized IALV under control perfusion with Krebs solution (A) and in response to 5 µM benzbromarone (B). The recorded action potentials were analyzed to assess: action potential frequency (C), resting membrane potential (D), the linear diastolic depolarization rate (E), action potential initiation threshold potential (F), the steepness of the action potential upstroke (G), peak voltage achieved during the action potential (H), the plateau voltage (I), and plateau duration (J). *, P < 0.05 comparing 5 µM benzbromarone versus Krebs at n = 6.

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