Figure 9.

The calculated heat capacity for the high-affinity binding of cAMP to the tetrameric HCN2 C-terminus is smaller than that for low-affinity binding. A graph showing the values for ΔH calculated at 25°C (black squares) and 10°C (black circles), which were determined in a previous study by our group (Chow et al., 2012). The calculated slopes yield heat capacity and are shown next to their respective relation in the graph. Values represent means ± SEM.

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