Shown is the cloned genomic sequence of the 5′ flanking region of the brain type II sodium channel gene that has hung on my office wall for over 20 yr. Sequences identified by red tape identify the repressor sequences that keep the promoter region (colocalized with coffee stains at bottom) off in nonneuronal cells. The repressor protein REST was shown ultimately to bind to the repressor sequences. Boxes encompass a specialized DNA sequence caused by a transposon insertion whose function is unknown but may someday make me famous.