Figure 5.
Figure 5. Effects of subunit liganding on deactivation kinetics. The currents were activated by pulses of 6-s duration to −140 mV, and deactivation was measured at a subsequent pulse to −30 mV. (A) Superimposition of two current time courses of the concatemer wwww in the absence and presence of cAMP and expanded deactivation time courses at −30 mV. Determination of the time of half-maximum deactivation thd is illustrated. (B) Comparison of τd,cAMP/τd,cont for the eight tetrameric concatemers and the dimeric concatemer wm2 (see text). At least two liganded subunits in trans position are required to decelerate deactivation. Data points contain 3–32 recordings. Error bars indicate SEM.

Effects of subunit liganding on deactivation kinetics. The currents were activated by pulses of 6-s duration to −140 mV, and deactivation was measured at a subsequent pulse to −30 mV. (A) Superimposition of two current time courses of the concatemer wwww in the absence and presence of cAMP and expanded deactivation time courses at −30 mV. Determination of the time of half-maximum deactivation thd is illustrated. (B) Comparison of τd,cAMP/τd,cont for the eight tetrameric concatemers and the dimeric concatemer wm2 (see text). At least two liganded subunits in trans position are required to decelerate deactivation. Data points contain 3–32 recordings. Error bars indicate SEM.

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