Impact of MB-001 and fenretinide administration on wild-type mouse cone-driven ERG responses. (A) Representative light-adapted ERGs obtained from 7-mo-old C57BL/6J mice administered vehicle and bleached, administered MB-001 and bleached, or administered MB-001 and not bleached. These photopic ERGs were recorded immediately after the scotopic recordings shown in Fig. 7 (A–C) and a 5-min light adaptation period under steady 30 cd/m2 background light, which was maintained during the recordings. Flash strength is color coded: blue, 0 log cd·s/m2; purple, 0.9 log cd·s/m2; red, 1.9 log cd·s/m2. (B) Photopic b-wave responses for the three treatment groups. Data points indicate means (±SEM) of five mice per group for the vehicle and MB-001 bleach groups and three mice for the MB-001 no-bleach group. Note that MB-001 reduced cone ERG amplitude recovery after a bleach and reduced cone ERG amplitude to a lesser extent in mice reared under standard vivarium lighting conditions. (C) Representative light-adapted ERGs obtained from 2-mo-old C57BL/6J mice administered vehicle and bleached or administered fenretinide and bleached. These photopic ERGs were recorded immediately after the scotopic recordings shown in Fig. 7 (D–F) and a 5-min light adaptation period under steady 30 cd/m2 background light, which was maintained during the recordings. Flash strength is color coded: black, −0.8 log cd·s/m2; blue, 0 log cd·s/m2; purple, 0.9 log cd·s/m2; red, 1.9 log cd·s/m2. (D) Photopic b-wave responses for the two treatment groups. Data points indicate the means (±SEM) of three mice per group. Note that light-adapted ERG b-wave amplitudes were slightly greater in mice treated with fenretinide as compared with those treated with vehicle.
