Cell volume–sensitive currents induced by the homomeric 8A-8C(EL1) chimeras. (A) Time course (left) and current–voltage relationships (middle) of resting, swelling-activated, and shrinkage-inactivated currents in Lrrc8^−/− HCT116 cells expressing the 8A-8C(EL1) chimera. Values are means ± SEM (n = 5). Right panel shows representative traces of swelling-activated currents induced by the chimera. (B) Time course (left) and current–voltage relationships (middle) of resting and shrinkage-inactivated currents and currents observed in hypotonic medium in Lrrc8^−/− HCT116 cells expressing the 8A-8C(P86–K125) chimera. Values are means ± SEM (n = 5). Right panel shows representative traces of currents induced by the chimera in isotonic medium.