Cell volume-sensitive currents induced by 8A + 8E heteromers and the homomeric 8E-8A(IL) chimera. (A) Time course (left) and current–voltage relationships (middle) of resting, swelling-activated and shrinkage-inactivated currents in Lrrc8^−/− HCT116 cells coexpressing LRRC8A and LRRC8E. Values are means ± SEM (n = 3). Right panel shows representative traces of swelling-activated currents induced by 8A + 8E heteromers. (B) Time course (left) and current–voltage relationships (middle) of resting, swelling-activated and shrinkage-inactivated currents in Lrrc8^−/− HCT116 cells expressing the 8E-8A(IL) chimera. Values are means ± SEM (n = 4–6). Right panel shows representative traces of swelling-activated currents induced by 8E-8A(IL) homomers.