Cell volume-sensitive currents induced by 8A + 8D heteromers and the homomeric 8D-8A(IL) chimera. (A) Time course (left) and current–voltage relationships (middle) of resting, swelling-activated, and shrinkage-inactivated currents in Lrrc8^−/− HCT116 cells coexpressing LRRC8A and LRRC8D. Values are means ± SEM (n = 4). Right panel shows representative traces of swelling-activated currents induced by 8A + 8D heteromers. (B) Time course (left) and current–voltage relationships (middle) of resting, swelling-activated, and shrinkage-inactivated currents in Lrrc8^−/− HCT116 cells expressing the 8D-8A(IL) chimera. Values are means ± SEM (n = 4–5). Right panel shows representative traces of swelling-activated currents induced by 8D-8A(IL) homomers.