Figure 2.

The amplitude of basal CaV1.2 current was reduced in myocytes from LCyphKO mice. (A) Representative families of Ca2+ currents evoked by depolarization from −40 mV to a range of potentials from −40 to 80 mV in 10-mV increments in cardiac myocytes from WT, LCyphHET (HET), and LCyphKO (KO) mice. (B) Mean peak current–voltage relationships recorded in cardiac myocytes derived from WT, LCyphHET, and LCyphKO mice (n = 8–14 mice). (C) Comparison of Ca2+ currents evoked by depolarization from −40 to 0 mV in cardiac myocytes from WT, LCyphHET, and LCyphKO mice (n = 8–12 mice). *, P < 0.05. Error bars indicate SEM.

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