Dynasore treatment impaired the ability of HCs to follow rod light responses. (A) An example of light-evoked currents (LEC) recorded from a dark-adapted HC while sinusoidally modulating a dim 580-nm light (19 photons/µm2/s) at 2 Hz to record rod-driven responses. The HC light response diminished during bath application of dynasore (80 µM) and then recovered after washout. (B) Power of HC light-evoked currents normalized to response power measured at 1-Hz stimulation. The enhancement of light-evoked currents in HCs at 2 Hz and attendant bandpass characteristics were diminished significantly by bath application of dynasore (P = 0.042, paired t test; control, n = 11; dynasore, n = 11). Responses recovered after washout (wash, n = 9). (C) Example of light-evoked voltage (LEV) responses from a rod evoked by 2-Hz modulation with 580-nm light (340 photons/µm2/s). (D) Response power of light-evoked voltage responses of rods normalized to the power measured at 1 Hz. Rod responses were not significantly affected by dynasore treatment (control, n = 10; dynasore, n = 10; wash, n = 7). Error bars represent ±SEM.
