Illustration of proposed conformational changes that occur in the intracellular domains and intrinsic ligand during VDP. Conformational change of the intrinsic ligand that is associated with the rearrangement of the eag domain and CNBHD during VDP. The CNBHD and C-linker domains are depicted in tetrameric form with one subunit colored for easier visualization. For clarity, only one subunit of an interacting intersubunit eag domain with its N-terminal PAS cap is shown. Linkers between the intracellular domains and the VSD/pore are not depicted. The N-terminal eag domain is linked to the VSD, whereas the C-terminal CNBHD is linked to the pore domain via the C-linker domains.