Flow autoregulation. (A–C) Total network flow under three levels of metabolic demand (q_target) in the subendocardial network with MVI (A) and without MVI (B) and subepicardial network with MVI (C). The vessels’ properties and boundary conditions are at their reference values (Table 1). The total flow in the presence of MVI remains nearly constant over the physiological autoregulation pressure range. MVI expands the perfusion pressure range for which autoregulation is effective. The autoregulatory behavior in the subepicardial tree is similar to the subendocardial tree without MVI.