The effects of different regulation mechanisms and of the terminal target flow q_target on the distribution across all terminal vessels of their time-averaged terminal flow $q ¯ t e r m$ . The vessels’ properties and the boundary conditions are their reference values (Table 1). The conducted metabolic length constant L₀ is 1 mm. (A) Flow distribution under myogenic and shear activation, only myogenic, shear, and full metabolic activation (all F_mterm = 1). (B) Flow distribution under myogenic, shear, and optimized metabolic regulation calculated to achieve target flows of 1.25, 1.5, and 1.75 × 10⁻³ mm³/s in the terminal vessels.