Relative positions of L358 and L361 residues from Shaker in the resting and active states as predicted by KV1.2 models. (A and B) Top view (A) and side view (B) of the resting state of the VSD as predicted by a structural- and functional-data-based consensus resting model (Vargas et al., 2011). The panels show S3 and S4 from the consensus model and S5, P-loop, and S6 from a neighbor channel subunit, from a crystallography-derived model of KV1.2 (PDB code 3LUT). Only pertinent residues are shown with spheres representing the Van der Waals volume of each atom. The color code is the following—magenta: residues I321, Y324, and T326 from S3; green: L358; red, L361. (C and D) Top view (C) and side view (D) of the active state of the VSD as predicted by a crystallography-derived model of KV1.2. Highlighted residues are also shown as spheres in the same way as in A and B, with residues L358 in green, L361 in red, and Y415 and F416, both from S5, in blue.
