Phosphorylation sites and potential PEST regions in human Ca_v2.3 channels. The secondary structure was visualized with Protter based on the human protein database entry Q15878, which includes exon 19 and exon 45 encoded stretches of the full-length Ca_v2.3d-splice variant. Predictions were performed at the highest threshold by using the Group-based System Software for Prediction of Kinase-specific Phosphorylation Sites 3.0 and at a threshold score of +5.0 by using epestfind for detection of potential proteolytic cleavage sites, respectively. CAMKI, Ca²⁺/CaM-dependent protein kinase I; CAMKII, Ca²⁺/CaM-dependent protein kinase II; CAMKL, Ca²⁺/CaM-dependent protein kinase-like kinases; MAPK, mitogen-activated protein kinase; SGK, serum and glucocorticoid-regulated kinase 1; ter, terminal.