Figure 8. K1591X CDI is mediated only by... | Rockefeller University Press

Figure 8.

$Figure 8. K1591X CDI is mediated only by CaM C lobe. (A) Representative traces and fractional ICa for ICa evoked by test pulse from −80 to −20 mV in cells transfected with K1591X alone or cotransfected with CaM12 or CaM34. P values were determined by Kruskal–Wallis ANOVA followed by post hoc Dunn's multiple comparison test. (B) Representative traces for ICa evoked by −20 mV pulse in cells transfected with Cav1.4Δex47 or K1591X. Inset shows superimposed ICa for Cav1.4Δex47 (black) and K1591X (gray) on expanded time scale. Bottom graphs show averaged data for time constants (τfast and τslow) and amplitudes (Afast and Aslow) obtained from double-exponential fits of ICa evoked as in A. P values were determined by Mann–Whitney test. Error bars represent mean ± SEM.$

K1591X CDI is mediated only by CaM C lobe. (A) Representative traces and fractional I_Ca for I_Ca evoked by test pulse from −80 to −20 mV in cells transfected with K1591X alone or cotransfected with CaM₁₂ or CaM₃₄. P values were determined by Kruskal–Wallis ANOVA followed by post hoc Dunn's multiple comparison test. (B) Representative traces for I_Ca evoked by −20 mV pulse in cells transfected with Ca_v1.4Δex47 or K1591X. Inset shows superimposed I_Ca for Ca_v1.4Δex47 (black) and K1591X (gray) on expanded time scale. Bottom graphs show averaged data for time constants (τ_fast and τ_slow) and amplitudes (A_fast and A_slow) obtained from double-exponential fits of I_Ca evoked as in A. P values were determined by Mann–Whitney test. Error bars represent mean ± SEM.