Figure 3. LPA induces an increase in current at both positive and negative potentials. (A and B) Representative traces for the currents elicited by 4 µM capsaicin (A) or by 5 µM LPA (B) at different potentials. The dashed line indicates zero-current level. (C) Summary of the microscopic current–voltage relations for capsaicin-elicited currents (black circles) and LPA-elicited currents (red triangles). Data are presented as mean ± SEM., n = 5. The increase in current is significant P 0.05 at −100, −60, −20, 60, and 100 mV (Student’s t test). Single-channel recordings were performed in the inside-out configuration of the patch clamp, with a holding potential of 0 mV and increasing square voltage pulses as indicated.
Figure 3.

LPA induces an increase in current at both positive and negative potentials. (A and B) Representative traces for the currents elicited by 4 µM capsaicin (A) or by 5 µM LPA (B) at different potentials. The dashed line indicates zero-current level. (C) Summary of the microscopic current–voltage relations for capsaicin-elicited currents (black circles) and LPA-elicited currents (red triangles). Data are presented as mean ± SEM., n = 5. The increase in current is significant P 0.05 at −100, −60, −20, 60, and 100 mV (Student’s t test). Single-channel recordings were performed in the inside-out configuration of the patch clamp, with a holding potential of 0 mV and increasing square voltage pulses as indicated.

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