Figure 3.
Figure 3. Locus of points {f, KI, KII} yielding perfect fit to a two-site binding curve calculated using correct values of model parameters {f*, KI*, KII*}. Correct values of fit parameters are then p1* = KI* + KII* and p2* = f* KI* KII*. Curve was computed using Eqs. 12a and 12b. Upper (bold) and lower (normal) arms of curve correspond to values of either KI and KII or KII and KI. Minimum value of cooperativity parameter, fmin, and maximum value of the larger of KI and KII are also indicated.

Locus of points {f, KI, KII} yielding perfect fit to a two-site binding curve calculated using correct values of model parameters {f*, KI*, KII*}. Correct values of fit parameters are then p1* = KI* + KII* and p2* = f* KI* KII*. Curve was computed using Eqs. 12a and 12b. Upper (bold) and lower (normal) arms of curve correspond to values of either KI and KII or KII and KI. Minimum value of cooperativity parameter, fmin, and maximum value of the larger of KI and KII are also indicated.

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