Figure 4.
![Figure 4. The inactivating phenotype of Kir6.2[R192A] is rescued by introduced Kir2.1 CD-I contacts. (A) Current response after initial patch excision of WT (black), R192A (blue), and R192A/H193D/T223R (red) channels, normalized to the peak current amplitude (Ipk). Steady-state current (Iss) shows the extent of channel inactivation. (B) Extent (1 − Iss/Ipk; left) and time course (τinact; right) of inactivation for CD-I mutations, from experiments as in Fig. 3. (C and D) Fold increase of steady-state (Iss; C) and initial (Ipk; D) current amplitude after PIP2 potentiation; means ± SEM; *, P < 0.05 relative to WT means; †, P < 0.05 relative to R192A means (Student’s t test).](https://cdn.rupress.org/rup/content_public/journal/jgp/149/5/10.1085_jgp.201611719/5/jgp_201611719_fig4.jpeg?Expires=1767769267&Signature=wG1wxsR9fFkG-fwwsd9IAeid3fjZZ7~CcHTZf3uuRFdMLdoklDuhyRUcRPhZ0grPYz0eSuKDKkX5bw1S7p6dUMX0P4FuCKdWlaJPFoFfNcl5~op8Q083dd3hTHdVqxaMpDjBqN6s16opp7F68jSJLdvPvWYc~IB6Ja0So7vOYEXNpLjpthrJraOJxr0CVlgVYvKRIOgwnfRCgNp3efFRAxbSv2C1-ce8CYNVddCQH1~zPtxbNbKwkjrebrmvBZ9zO2KYl0wCRRNCsvHb-dcSmnAxbM3ncAlROIReJ8xRZikaBRdz9xAMkyaRE54b8refzHTBSBhG8CsM77xCKO~Vkg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The inactivating phenotype of Kir6.2[R192A] is rescued by introduced Kir2.1 CD-I contacts. (A) Current response after initial patch excision of WT (black), R192A (blue), and R192A/H193D/T223R (red) channels, normalized to the peak current amplitude (Ipk). Steady-state current (Iss) shows the extent of channel inactivation. (B) Extent (1 − Iss/Ipk; left) and time course (τinact; right) of inactivation for CD-I mutations, from experiments as in Fig. 3. (C and D) Fold increase of steady-state (Iss; C) and initial (Ipk; D) current amplitude after PIP2 potentiation; means ± SEM; *, P < 0.05 relative to WT means; †, P < 0.05 relative to R192A means (Student’s t test).
